ArticleFrontiers in neuroscience2026
Short-term amblyopic eye deprivation boosts the binocular intermodulation in anisometropic amblyopia.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: We tested whether short-term monocular deprivation (STMD) of the amblyopic eye enhances binocular intermodulation steady-state visual evoked potentials (SSVEPs), reflecting reduced suppression from the fellow eye. Methods: Fifteen anisometropic amblyopes (15.6 ± 5.8 years) underwent 2-h STMD of their fellow eye on the first day, followed by a similar session on their amblyopic eye on the second day. We recorded SSVEPs from 21 occipital electrodes pre/post STMD during binocular rivalry (6/7.5 Hz flicker). Results: Similar to the previous study, the monocular SSVEP amplitude of the deprived eye increased after STMD, whereas that of the non-deprived eye remained unchanged. Critically, STMD of the amblyopic eye significantly increased f Conclusion: STMD of the amblyopic eye, but not the fellow eye, significantly enhanced binocular SSVEP intermodulation. Baseline f1+f2 amplitude predicted the magnitude of plasticity, suggesting its potential as an electrophysiological biomarker for reverse deprivation therapy.
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