An AuNP-labeled triple-helix molecular switch for ultrasensitive, on-site detection of tetracycline in milk via fiber-optic localized surface plasmon resonance biosensing.

Xuqi Situ, Jiacong Li, Yeshun Zhang, Hui Yan

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Article in Food chemistry: X, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 authors.

Xuqi SituSchool of biotechnology, Jiangsu University of Science and technology, Zhenjiang 212100, China.

Jiacong LiSchool of biotechnology, Jiangsu University of Science and technology, Zhenjiang 212100, China.

Yeshun ZhangSchool of biotechnology, Jiangsu University of Science and technology, Zhenjiang 212100, China.

Hui YanSchool of biotechnology, Jiangsu University of Science and technology, Zhenjiang 212100, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To meet the urgent demand for monitoring tetracycline residues in milk-a critical food for vulnerable groups a novel fiber-optic Localized Surface Plasmon Resonance (LSPR) biosensor was engineered using gold-nanoparticle-labeled DNA triple-helix switches. The sensor operates via a target-activated disassembly: tetracycline binding dissociates the immobilized triple-helix, releasing gold nanoparticles and inducing a measurable LSPR blue shift. This active displacement amplifies the signal via localized refractive-index changes, enabling rapid, label-free detection. The sensor achieved excellent performance, with a linear range of 5-100 ng/mL and a low detection limit of 0.28 ng/mL. When applied to real milk samples, it delivered excellent recovery rates of 96.75%-104.15% (RSD <5.1%) and showed no statistically significant difference (

Indexed as

fiber-optic biosensorFood safetyLocalized surface plasmon resonanceTetracyclineTriple-helix molecular switch

Identifiers

PMID41994547

DOI10.1016/j.fochx.2026.103782

PMCPMC13081666

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.