Evidence map›Paper›PMID 41994490›Full record

ArticleJournal of the Endocrine Society2026

Clinical and genetic characteristics of head and neck paragangliomas from China featuring Sino-European comparisons.

Jun Liu, Yingxian Pang, Jianing Yue, Yanting Shen, Jing Zhang, Minghao Li, Xiaowen Xu, Bin Chen, Jue Yang, Daqiao Guo and 9 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Jun LiuDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yingxian PangDepartment of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.
Jianing YueDepartment of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Yanting ShenDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Jing ZhangDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Minghao LiDepartment of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.
Xiaowen XuDepartment of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.
Bin ChenDepartment of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Jue YangDepartment of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Daqiao GuoDepartment of Vascular Surgery, Zhongshan Hospital Fudan University, Shanghai 200032, China.
Jing WangDepartment of Pathology, Xiangya Hospital, Central South University, Changsha 410008, China.
Henri J L M TimmersDepartment of Internal Medicine, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.ORCID https://orcid.org/0000-0002-1208-5748
Christina PamporakiDepartment of Medicine III, Medical Faculty Carl Gustav Carus, University Hospital Carl Gustav Carus, Technische Universität Dresden, 01307 Dresden, Germany.
Henricus P M KunstDepartment of Otorhinolaryngology, Dutch Academic Alliance Skull Base Pathology, Radboud University Medical Center, 6525 GA Nijmegen, The Netherlands.
Longfei LiuDepartment of Urology, Xiangya Hospital, Central South University, Changsha 410008, China.ORCID https://orcid.org/0000-0003-0274-4057
Zhiqiang LuDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0003-1073-6313
Zhiyin ZhangDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0003-2335-228X
Susan RichterAuckland Cancer Society Research Centre, School of Medical Sciences, University of Auckland, Auckland 1142, New Zealand.
Jingjing JiangDepartment of Endocrinology and Metabolism, Zhongshan Hospital Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0003-1886-2613

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Head and neck paragangliomas (HNPGLs) are tumors of parasympathetic origin, predominantly associated with pseudohypoxia and pathogenic variants (PVs) in succinate dehydrogenase (SDH) subunits, mainly based on studies in Europeans/Americans. Objective: This work aimed to assess the genetics of HNPGLs in a large Chinese cohort and compare them with European cases. Methods: A retrospective cohort study was conducted of HNPGLs from 2 Chinese tertiary-care centers and 2 European centers. Participants included 222 Chinese and 205 European HNPGL patients. Main outcome measures included clinical presentation and genetic status assessed via next-generation sequencing of tumor/blood samples. Results: The Chinese HNPGL cohort consisted mainly of carotid body HNPGLs (86.9%), fewer jugulotympanic (12.2%), and no vagal HNPGLs. Jugulotympanic HNPGLs showed higher recurrence than carotid body HNPGLs (30.4% vs 8.5%; Conclusion: This is the first report of HNPGLs in a large Chinese cohort. Clinical presentation and practice as well as ancestry all likely contribute to the differences observed between Chinese and European patients.

Indexed as

Chinese ancestrygeneticshead and neck paragangliomas

Identifiers

PMID41994490
PMCPMC13079993

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.