ArticleJournal of the Endocrine Society2026
The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues.
Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- The sphingosine-1-phosphate pathway is differentially activated in human gestational tissues.Journal of the Endocrine Society · 2026Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Background: Dysregulated myometrial contractility contributes to obstetric complications. Sphingosine-1-phosphate (S1P), a bioactive lipid, modulates inflammation and smooth muscle contractility, including uterine contractility. However, its metabolic dynamics during pregnancy are poorly characterized. This study profiled S1P metabolic enzymes and receptors, and quantified sphingolipid metabolites in human gestational tissues across pregnancy. Methods: Myometrium, decidua parietalis, and chorioamnion were collected from women undergoing cesarean sections at term (≥37 weeks' gestation) without labor (TNL, Results: S1P metabolic enzymes and receptors were differentially expressed across gestational tissues. At TNL, sphingosine kinase1 ( Conclusion: These findings reveal tissue-specific regulation of S1P metabolism and signaling in human gestational tissues, suggesting S1P's therapeutic role to modulate myometrial contractility.
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