Evidence map›Paper›PMID 41994485›Full record

ArticleJournal of the Endocrine Society2026

TS3 Asn347 corticosteroid-binding globulin (CBG) glycoform deficiency is associated with mortality in human septic shock.

Jessica H Lee, Zeynep Sumer-Bayraktar, R Louise Rushworth, Anastasia Chernykh, Marni Nenke, Morten Thaysen-Andersen, Emily J Meyer, David J Torpy

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Article in Journal of the Endocrine Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Jessica H LeeDepartment of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.ORCID https://orcid.org/0000-0001-8643-1773
Zeynep Sumer-BayraktarSchool of Natural Sciences, Macquarie University, Sydney, NSW 2113, Australia.ORCID https://orcid.org/0000-0001-7064-2728
R Louise RushworthSchool of Medicine, The University of Notre Dame, Sydney, NSW 2010, Australia.
Anastasia ChernykhSchool of Natural Sciences, Macquarie University, Sydney, NSW 2113, Australia.
Marni NenkeDepartment of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
Morten Thaysen-AndersenSchool of Natural Sciences, Macquarie University, Sydney, NSW 2113, Australia.ORCID https://orcid.org/0000-0001-8327-6843
Emily J MeyerDepartment of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.
David J TorpyDepartment of Medicine, University of Adelaide, Adelaide, SA 5000, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Context: Corticosteroid-binding globulin (CBG) deficiency is an independent predictor of intensive care unit (ICU) mortality in septic shock. CBG glycosylation at the Asn347 site affects neutrophil elastase cleavage susceptibility, altering CBG:cortisol binding affinity, and may underlie this association. Objective: This work aimed to analyze CBG Asn347 glycoforms in patients with septic shock and determine their relationship to mortality and illness severity. Methods: CBG Asn347 site glycosylation profiling was performed by mass spectrometry in 128 septic shock patients from a tertiary hospital ICU at day 1 and last day of admission up to 7 days. ICU and 28-day mortality were analyzed by a Cox proportional hazards model, sequentially correcting for illness severity (APACHE score) and total CBG (all glycoforms). Results: Only triantennary trisialylated (TS3) Asn347 CBG glycoform concentrations were lower in ICU septic shock nonsurvivors than in survivors (29.74 vs 45.16 nmol/L; Conclusion: Deficiency of the Asn347 TS3 CBG glycoform is associated with ICU and 28-day mortality in septic shock.

Indexed as

CBGcorticosteroid-binding globulinglycosylationseptic shock

Identifiers

PMID41994485
PMCPMC13079443

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.