Evidence map›Paper›PMID 41994453›Full record

ArticleFrontiers in medicine2026

Characterization of the aqueous humor microbiome in Posner-Schlossman syndrome: an exploratory metagenomic sequencing study.

Weijia Zhang, Ke Zhang, Yanfeng Liao, Zhen Yang, Ziyao Xia, Xianghan Ke, Di Zhang, Jing Chen, Hongling Wu, Ying Hong and 5 more

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

15 authors.

Weijia Zhang *Beijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Ke Zhang *Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yanfeng LiaoDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Zhen YangDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Ziyao XiaBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Xianghan KeDepartment of Ophthalmology, Sinopharm Chongqing Yangtze Shipping Hospital, Chongqing, China.
Di ZhangBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Jing ChenHangzhou Matridx Biotechnology Co., Ltd., Hangzhou, China.
Hongling WuBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Ying HongDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Huaizhou WangBeijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.
Ziyuan LiuDepartment of Ophthalmology, Peking University Third Hospital, Beijing, China.
Lingge Suo *Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Yu Zhang *Department of Ophthalmology, Peking University Third Hospital, Beijing, China.
Chun Zhang *Beijing Tsinghua Changgung Hospital Eye Center, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: This study aims to characterize the aqueous humor (AH) microbiome in Posner-Schlossman syndrome (PSS) patients and evaluate its potential as a diagnostic and therapeutic target. Methods: Metagenomic next-generation sequencing (mNGS) was performed on 59 AH samples from patients diagnosed with PSS ( Results: Key findings revealed that intraocular microbiomes existed in both normal and diseased eyes; however, PSS patients exhibited lower microbial diversity (Shannon index, Conclusion: Our study provides preliminary evidence supporting the concept of intraocular microbiome dysbiosis in PSS, which requires validation in future studies. These findings suggest that potential microbial biomarkers warrant further investigation for their diagnostic and therapeutic implications.

Indexed as

aqueous humorexploratory studymetagenomic next-generation sequencingocular microbiotaPosner–Schlossman syndrome

Identifiers

PMID41994453
PMCPMC13079188

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.