ArticleFrontiers in medicine2026
Long-term impact of antibiotic exposure duration on recurrence and microbial resistance in moderate-to-severe acne: a real-world retrospective analysis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Systemic antibiotics for moderate-to-severe acne are commonly prescribed, but the optimal duration remains unclear. Prolonged use may increase recurrence rates and antibiotic resistance. This study evaluated the long-term effects of antibiotic duration on acne recurrence and microbial resistance. Methods: This study included a single-center retrospective cohort of 240 patients (12-40 years) with moderate-to-severe acne treated with doxycycline or minocycline (2020-2023). Patients were stratified into groups by duration: short-term (6-12 weeks, Results: The 12-month recurrence rates increased in a duration-dependent manner: 23.8% (short-term duration), 35.0% (standard-term duration), and 46.3% (prolonged duration) ( Conclusion: Extended antibiotic therapy for acne was associated with an increased 12-month recurrence risk without improving short-term outcomes, consistent with guideline recommendations to limit duration and emphasize antimicrobial stewardship.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.