Association between the imbalance in peripheral lymphocyte subsets and pneumonia-associated acute respiratory distress syndrome in adults: a cross-sectional study.

Zhen-Chuan Xing, Hua-Zheng Guo, Ting Ao, Jin-Xiang Wang, Ming Hu

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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5 · Who and what money

Authors and funding

5 authors.

Zhen-Chuan XingDepartment of Pulmonary and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Hua-Zheng GuoDepartment of Infectious Disease, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Ting AoDepartment of Infectious Disease, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Jin-Xiang WangDepartment of Pulmonary and Critical Care Medicine, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Ming HuDepartment of Infectious Disease, Beijing Luhe Hospital, Capital Medical University, Beijing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Acute respiratory distress syndrome (ARDS) is a severe complication of pneumonia that significantly increases mortality. Its pathogenesis is associated with dysregulated host immune responses, which has been a topic of global research in lung injury. Methods: In this cross-sectional study, we enrolled adult patients with pneumonia from the Department of Infectious Diseases between May 2021 and June 2025. Participants were categorized into ARDS and non-ARDS groups based on the presence of ARDS at admission. We employed multivariable logistic regression and restricted cubic spline models to evaluate the association between lymphocyte subset levels and ARDS, adjusting for key clinical confounders. Results: Of the 227 eligible patients, 127 were diagnosed with ARDS. Patients with ARDS exhibited lower CD3 Conclusion: This study indicates an independent inverse association between CD3

Indexed as

acute respiratory distress syndromeimmunophenotypinglymphocyte subsetspneumoniarisk factors

Identifiers

PMID41994426

DOI10.3389/fmed.2026.1753313

PMCPMC13079331

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.