ArticleLaryngoscope investigative otolaryngology2026
The Impact of Acid-Free Reflux on Vocal Cord Granuloma.
Article in Laryngoscope investigative otolaryngology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: To examine the types and characteristics of acid-free reflux in vocal cord granuloma (VCG). Methods: A retrospective analysis was conducted on the VCG patients and those with benign unilateral vocal cord lesions between October 2017 and January 2025. Prior to treatment, all patients underwent 24-h hypopharyngeal-esophageal multichannel intraluminal impedance-pH (HEMII-pH) monitoring, high-resolution esophageal manometry assessment, and electronic laryngoscopy examination. Furhermore, granuloma tissue samples from the VCG patients were obtained for detection of pepsin, pepsinogen A, pepsinogen C and trypsin, using immunohistochemical analysis. Results: The proportion of the VCG group experiencing acid-free reflux was significantly higher than that observed in the benign lesion group (65.57% ± 23.26% vs. 30.43% ± 18.53%, Conclusion: Acid-free reflux could potentially play a significant role in the development of granulomas in VCG patients. Level of Evidence: 4.
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