Evidence map›Paper›PMID 41994268›Full record

ArticleFrontiers in microbiology2026

The enhancing therapeutic effect of neonatal jaundice by

Feng Zhang, Jiayi Chen, Yanhan Yuan, Juanjuan Chen, Wei Jiang, Weiwei Xiang, Na Wang, Zhimin Wu, Sainan Fan, Kun Zhang and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Feng Zhang *College of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Jiayi Chen *Department of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Yanhan YuanDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Juanjuan ChenDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Wei JiangLaboratory of Microbiology, Immunology, and Metabolism, Diprobio (Shanghai) Co, Limited, Shanghai, China.
Weiwei XiangLaboratory of Microbiology, Immunology, and Metabolism, Diprobio (Shanghai) Co, Limited, Shanghai, China.
Na WangDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Zhimin WuDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Sainan FanDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Kun ZhangDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Yanan MaDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Tianyu LiuCollege of Food Science and Technology, Shanghai Ocean University, Shanghai, China.
Jiahui ZhangDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.
Qinghua YuLaboratory of Microbiology, Immunology, and Metabolism, Diprobio (Shanghai) Co, Limited, Shanghai, China.
Jinping ZhangDepartment of Pediatrics, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, DiproX Medical Research Center, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hyperbilirubinemia is among the most common conditions in neonates, and phototherapy is currently the most widely used treatment. However, it can induce side effects such as skin rashes, diarrhea, and gut microbiota dysbiosis, particularly affecting Methods: A total of 79 jaundiced neonates were enrolled and divided into four groups: Phototherapy Control, M-16V, Bb-12, and the combined M-16V+Bb-12 group. Probiotics were administered until 30 days post-discharge, and neurodevelopment was assessed at 1.5-2 years using the Griffith Development Scales. Fecal samples collected before, during, and after treatment were analyzed using metagenomic sequencing and non-targeted metabolomics. Results: Probiotic supplementation significantly increased daily defecation frequency, accelerated the reduction rate of transcutaneous bilirubin, and shortened hospital stays. Griffith scores indicated that Bb-12 supplementation improved scores in personal-social and performance domains. Metagenomic analysis revealed significant differences in beta diversity between the control and probiotic groups; specifically, M-16V and combined supplementation increased the abundance of Discussion: For neonates receiving phototherapy, the addition of M-16 V + Bb-12 probiotics can improve the diversity of microflora, reduce the fixed value of harmful bacteria in the intestine, and enhance the excretion of bilirubin from the intestine, to improve the inflammatory damage and microbiota disorder caused by phototherapy, and achieve the effect of clinically improving jaundice, reducing bilirubin, shortening the length of hospitalization, and promoting neurodevelopment. It provides a safer and more effective treatment for neonatal jaundice.

Indexed as

bilirubin metabolismgut microbiotaneonatal jaundiceprobioticsrepair of inflammatory injury

Identifiers

PMID41994268
PMCPMC13079629

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.