ArticleReproductive medicine and biology
Letrozole Reduces Ovulatory Responsiveness in In Vitro-Grown Mouse Follicles.
Article in Reproductive medicine and biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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8 authors.
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Abstract
Purpose: This study aimed to determine whether continuous aromatase inhibition with letrozole reduces peri-ovulatory responsiveness to ovulatory stimulation in in vitro-grown mouse follicles. Methods: Early antral follicles were isolated from 21 to 24-day-old C57BL/6jjcl mice and cultured individually for 5 days with letrozole (0.01, 0.1, or 1 μM) or vehicle. Follicle survival and growth were assessed by measuring follicle diameter. Ovulatory responsiveness was evaluated by hCG/EGF stimulation. Expression of ovulation-related genes ( Results: Letrozole did not affect follicle survival or growth. However, ovulation rates were reduced in a dose-dependent manner ( Conclusions: Continuous letrozole exposure reduces ovulatory responsiveness in in vitro-grown mouse follicles and is associated with decreased Lhcgr expression after hCG stimulation, likely due to estrogen deficiency. These findings suggest that prolonged aromatase inhibition during follicular growth may impair acquisition of peri-ovulatory competence.
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