Evidence map›Paper›PMID 41994200›Full record

ArticleFrontiers in cellular and infection microbiology2026

The value of serum CARDS toxin and NETs formation in children with MPP.

Wanyu Jia, Ruiyang Sun, Jiapu Hou, Zewen Ding, Peng Li, Chunlan Song

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Wanyu JiaHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.
Ruiyang SunHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.
Jiapu HouHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.
Zewen DingHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.
Peng LiHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.
Chunlan SongHenan Province Engineering Research Center of Diagnosis and Treatment of Pediatric Infection and Critical Care, Children's Hospital Affiliated to Zhengzhou University, Henan Children's Hospital, Zhengzhou Children's Hospital, Zhengzhou, Henan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cardiopulmonary Distress Syndrome Toxin (CARDS TX) is a key virulence factor of Methods: Children hospitalized at Henan Children's Hospital in 2023 with MPP were enrolled and divided into the GMPP group and SMPP group. Serum levels of CARDS TX, citrullinated histone 3 (CitH3) and myeloperoxidase (MPO), were measured in both groups. Comparative analysis of marker levels between groups was conducted. Diagnostic utility for identifying SMPP was evaluated using logistic regression analysis and receiver operating characteristic ROC curves. Results: A total of 147 children with mycoplasma pneumonia were included in this study, among which 74 were in the SMPP group and 73 were in the GMPP group. The levels of serum CARDS TX, MPO, and CitH3 in the SMPP group were significantly higher than those in the GMPP group. The levels of serum CARDS TX, MPO, and CitH3 were significantly positively correlated with SMPP, with correlation coefficients of 0.433, 0.357, and 0.396 respectively. The results of multivariate logistic analysis showed that CARDS TX, MPO, and CitH3 were risk factors for SMPP. The AUC of serum CARDS TX, MPO, and CitH3 levels for predicting SMPP were 0.750, 0.706, and 0.729 respectively, with cut-off values of 7.9 pg/ml, 181.16 ng/ml, and 150.38 ng/ml. Conclusion: The elevated levels of serum CARDS TX, MPO, and CitH3 are independent risk factors for SMPP, and these three indicators have good predictive value for SMPP. CARDS TX secreted by MP may contribute to SMPP development by inducing excessive NET formation.

Indexed as

Bacterial ProteinsBacterial ToxinsExtracellular TrapsMycoplasma pneumoniaePneumonia, MycoplasmaBiomarkersChildChild, PreschoolFemaleHistonesHumansMalePeroxidaseROC CurveVirulence FactorsBacterial ProteinsBacterial ToxinsBiomarkersHistonesPeroxidaseVirulence FactorsCARDS TXcitrullinated histones 3mycoplasma pneumoniae pneumoniamyeloperoxidaseneutrophil extracellular traps

Identifiers

PMID41994200
PMCPMC13079613

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