Evidence map›Paper›PMID 41994194›Full record

ArticleMicroplastics and nanoplastics2026

Methodology, characterization, and multiple-path particle dosimetry modeling of laboratory inhalation exposure for micro-nanoplastic particles in rodents.

Gina M Moreno, Justin Kidd, Marcus A Garcia, Sabrina Farias, Justin Scott, Jorge Gonzalez-Estrella, Richard M Cavalere, Andrea J Tiwari, Phoebe A Stapleton

Abstract read
In one paragraph

Article in Microplastics and nanoplastics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gina M MorenoDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
Justin KiddDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.
Marcus A GarciaDepartment of Pharmaceutical Sciences, College of Pharmacy, University of New Mexico Health Sciences, Albuquerque, NM, USA.
Sabrina FariasSchool of Civil and Environmental Engineering, Oklahoma State University, Stillwater, OK, USA.
Justin ScottSchool of Civil and Environmental Engineering, Oklahoma State University, Stillwater, OK, USA.
Jorge Gonzalez-EstrellaSchool of Civil and Environmental Engineering, Oklahoma State University, Stillwater, OK, USA.
Richard M CavalereTSI Incorporated, 500 Cardigan Rd, Shoreview, MN, USA.
Andrea J TiwariTSI Incorporated, 500 Cardigan Rd, Shoreview, MN, USA.
Phoebe A StapletonDepartment of Pharmacology and Toxicology, Ernest Mario School of Pharmacy, Rutgers University, Piscataway, NJ, USA.

Funding

Translational Research Support CoreP30ES005022 · NIEHS · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI BRIAN T BUCKLEY · 1988 to 2026
$47.4M
University of New Mexico Center for Metals in Biology and Medicine - equipment supplementP20GM130422 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI Sebastian Medina · 2020 to 2026
$20.4M
TRAINING IN EVIRONMENTAL TOXICOLOGYT32ES007148 · NIEHS · RUTGERS THE ST UNIV OF NJ NEW BRUNSWICK · PI Lauren M Aleksunes · 1987 to 2026
$11.4M
Accumulation of micro- and nanoplastic particles in mammalian tissues: a translational studyR01ES036575 · NIEHS · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI FLORSHEIM, REBECCA, STAPLETON, PHOEBE · 2025 to 2025
$5.5M
Microvascular mechanisms of growth restriction after environmental toxicant exposureR01ES031285 · NIEHS · RUTGERS, THE STATE UNIV OF N.J. · PI STAPLETON, PHOEBE · 2021 to 2025
$3.5M
Supplement for Role of Environmental Weathering and Gastrointestinal Digestion on the Bioavailability and Toxicity of Microplastic and Cadmium MixturesR15ES034901 · NIEHS · OKLAHOMA STATE UNIVERSITY STILLWATER · PI GONZALEZ ESTRELLA, JORGE · 2023 to 2023
$665k
NIEHS NIH HHS P30 ES005022NIEHS NIH HHS R01 ES031285NIEHS NIH HHS R01 ES036575NIEHS NIH HHS R15 ES034901NIEHS NIH HHS T32 ES007148NIGMS NIH HHS P20 GM130422
6 · The paper itself

Abstract

Plastics are ubiquitous in all trophic environments. Human exposures primarily occur via ingestion, inhalation, and/or injection routes. However, laboratory models of micro- and nanoplastic (MNP) particle exposures replicating the human condition remain inconsistent and uncharacterized, thus limiting study strength and compromising the reliability of results. The purpose of this study was to thoroughly optimize and characterize an established methodology for MNP rodent inhalation exposures, and to model particle respiratory deposition to estimate theoretical in silico exposures in rats and humans for the assessment of MNP health effects. Using our whole-body rodent inhalation facility, we generated MNP aerosols after thorough material characterization of a commercially available food-grade polyamide-12 (PA-12) bulk microparticle powder. PA-12 particulate was thoroughly assessed via pyrolysis-gas chromatography-mass spectrometry (PY-GC-MS), attenuated total reflectance-Fourier-transform infrared (ATR-FTIR) spectroscopy, and helium ion microscopy (HIM) to confirm material chemistry, size, and surface shape. Representative MNP were established and measured at three mass concentrations, low (1.01 mg/m

Indexed as

CharacterizationExposureInhalationMicro- and nanoplasticMultiple path particle dosimetryPolyamide-12

Identifiers

PMID41994194
PMCPMC13082836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.