Evidence map›Paper›PMID 41994188›Full record

ArticleIJTLD open2026

Stakeholder engagement to identify barriers to implementation and inform the development of point-of-care diagnostics for TB.

I Salles, E Lessem, L Walshe, B Myrzaliev, N B Hoa, M Shah, R E Chaisson, Y C Manabe

Abstract read
In one paragraph

Article in IJTLD open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

I SallesDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
E LessemDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
L WalsheDepartment of International Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
B MyrzalievKNCV TB Foundation, Branch Office KNCV in Kyrgyzstan, Bishkek, Kyrgyzstan.
N B HoaVietnam National Lung Hospital, Vietnam National Tuberculosis Program, Hanoi, Vietnam.
M ShahDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
R E ChaissonDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Y C ManabeDivision of Infectious Diseases, Johns Hopkins University School of Medicine, Baltimore, MD, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRapid TB diagnosis is crucial for improving outcomes and reducing transmission, yet nearly one third of cases remain undiagnosed or unreported. Point-of-care (POC) diagnostics are critical for bridging this gap.

methodsWe surveyed stakeholder priorities for TB POC diagnostics to inform development aligned with global needs. An online survey was disseminated through SMART4TB partner networks over 13 weeks. The survey captured preferences for diagnostic features, testing obstacles, and attributes to strengthen TB response. Ranked preferences were analysed using weighted scoring with subgroup comparisons.

resultsOf 274 respondents, 89% were from high-burden countries and represented diverse stakeholders; 57% (155/274) were TB care providers. Accuracy and rapid turnaround time to results were top diagnostic features. Primary obstacles were external sample transport and consumables availability. Key attributes to effective TB response included sensitive POC tests, close follow-up, and more personnel training to recognise TB. Paediatric TB screening training was infrequent, with 53% rarely or never trained.

conclusionAccuracy and rapid turnaround are priority attributes for new TB POC diagnostics. Overcoming systemic barriers, including robust systems for identifying those who need screening, sample transport, material availability, and care continuity, is critical to achieving the successful implementation, and full impact of POC diagnostics.

Indexed as

capacity buildinghealth care deliveryimplementation barriersstakeholder engagementtraining gapstuberculosis

Identifiers

PMID41994188
PMCPMC13080304

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.