ArticleClinical case reports2026
Leukocyte Adhesion Deficiency in a 42-Day-Old Infant: A Case Report.
Article in Clinical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Leukocyte Adhesion Deficiency (LAD) is a rare primary immunodeficiency characterized by impaired leukocyte adhesion and migration, resulting in recurrent bacterial infections, poor wound healing, and delayed umbilical cord separation. We report a 42-day-old female infant who presented with recurrent skin infections and delayed cord detachment in the absence of fever and purulent discharge. Flow cytometry showed markedly reduced CD18 expression (1.8%), and genetic analysis confirmed a homozygous ITGB2 mutation (c.844C>T; p.Arg282Trp), consistent with LAD Type I. Neutrophil oxidative burst was normal, excluding chronic granulomatous disease. Early diagnosis allowed timely initiation of prophylactic antibiotics and close follow-up to prevent complications. This case emphasizes the diagnostic importance of recognizing infection without pus and delayed umbilical separation as hallmark features of LAD.
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