ArticleResearch square2026
A Robust, High-Content NAM for Repeatable and Predictive Developmental and Reproductive Toxicity Assessment in C. elegans.
Sudip Mondal, Adam Laing, Amber Shen, Evan Hegarty, Abhishri Medewar, Sebastian Gomez, Gina Carrion, Julia Brown, Adela Ben-Yakar
Abstract readPreprint
In one paragraphArticle in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
9 authors.
Sudip MondalvivoVerse, LLC.
Adam LaingvivoVerse, LLC.
Amber ShenvivoVerse, LLC.
Evan HegartyvivoVerse, LLC.
Abhishri MedewarvivoVerse, LLC.
Sebastian GomezvivoVerse, LLC.
Gina CarrionvivoVerse, LLC.
Julia BrownvivoVerse, LLC.
Adela Ben-YakarThe University of Texas at Austin.
Funding
A Multiwell Plate Format Microfluidic Immobilization Chip for High-Content Imaging of Whole Animals for in vivoNeurotoxicology TestingR44MH118841 · NIMH · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2020 to 2022
$2.2MThe Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans PopulationsR44ES033579 · NIEHS · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2023 to 2024
$1.8MHigh-content study to analyze the nutritional value of natural products for healthy agingR43AT013187 · NCCIH · VIVOVERSE, LLC · PI MONDAL, SUDIP · 2025 to 2025
$307kHigh-Content in vivo DNT Test Batteries using Cell-Specific Characterization of the Neurodevelopment and Synaptogenesis in C. elegans as NAMsR43ES036387 · NIEHS · VIVOVERSE, LLC · PI MONDAL, SUDIP · 2024 to 2024
$287kA multiwell plate format microfluidic immobilization chip for high-content imaging of whole animalsR43MH118841 · NIMH · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2018 to 2019
$273kThe Next-Generation Developmental and Reproductive Toxicology (DART) Assay using High-Content Analysis of Genetically Diverse C. elegans PopulationsR43ES033579 · NIEHS · VIVOVERSE, LLC · PI HEGARTY, EVAN · 2021 to 2021
$254kNCCIH NIH HHS R43 AT013187NIEHS NIH HHS R43 ES033579NIEHS NIH HHS R43 ES036387NIEHS NIH HHS R44 ES033579NIMH NIH HHS R43 MH118841NIMH NIH HHS R44 MH118841
6 · The paper itselfAbstract
Developmental and Reproductive Toxicity (DART) assessment is essential for product safety evaluation and currently relies heavily on vertebrate models that are costly, time-consuming, and resource-intensive.
Indexed as
acceptance criteriaC. elegansDevelopmental and reproductive toxicology (DART)high-resolution imagingin utero embryo phenotypemicrofluidic technologynew approach methodology (NAM)repeatable assaysstandard operating procedure (SOP)
Identifiers
PMID41994143
PMCPMC13082149
What OpenQuestion holds
Textmetadata
LicenceCC BY
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