Evidence map›Paper›PMID 41994137›Full record

ArticleResearch square2026

Reduced Affiliative Behavior in Autism Reflects Greater Dependence on Perceived Similarity.

Yu Hao, Alessandra N C Yu, Sarah M Banker, Matthew Schafer, Ember Zhang, Sarah Barkley, Jadyn Trayvick, Arabella W Peters, Abigaël A Thinakaran, Christopher McLaughlin and 3 more

Abstract readPreprint
In one paragraph

Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Yu HaoDepartment of Psychology, Ningbo University, Ningbo, Zhejiang, China.ORCID 0000-0002-3342-9132
Alessandra N C YuNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0001-9852-7131
Sarah M BankerDepartment of Child and Adolescent Psychiatry, NYU Grossman School of Medicine.
Matthew SchaferSchool of Medicine, Columbia University.
Ember ZhangSchool of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA, USA.
Sarah BarkleyDepartment of Psychology, Stony Brook University.
Jadyn TrayvickDepartment of Psychology, Stony Brook University.
Arabella W PetersDepartment of Psychology, Montclair State University.
Abigaël A ThinakaranSeaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Christopher McLaughlinColumbia University Irving Medical Center.
Xiaosi GuPsychiatry and Biomedical Informatics & Data Science, Yale University.ORCID 0000-0002-9373-987X
Jennifer H Foss-FeigDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Daniela SchillerNash Family Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, USA.ORCID 0000-0002-0357-7724

Funding

Conduits: Mount Sinai Health System Translational Science HubUL1TR004419 · NCATS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Rosalind J Wright · 2022 to 2026
$46.4M
Neurocomputational mechanisms of proactive social behavior deficits in autism spectrum disorderR01MH122611 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI FOSS-FEIG, JENNIFER, GU, XIAOSI · 2020 to 2024
$3.9M
NCATS NIH HHS UL1 TR004419NIMH NIH HHS R01 MH122611
6 · The paper itself

Abstract

Social difficulties in autism are often framed as reduced motivation, yet this account does not explain when and why autistic individuals affiliate. We show that autism selectively alters the architecture-not the presence-of similarity-based social behavior. Across two independent samples (online, n = 714; in-person, n = 225), autistic and neurotypical adults exhibited comparable context-dependent (selective) preference for relatively similar others. In contrast, autistic individuals showed a markedly stronger global coupling between perceived similarity and affiliative behavior, such that low perceived similarity was associated with sharply reduced affiliation. This effect was strongest among those with lower trait empathy. Structural MRI revealed dissociable contributions of hippocampal and posterior cingulate cortex volumes to this coupling across groups. These findings demonstrate that autism preserves similarity attraction while amplifying its role as a stable heuristic for social engagement, supporting a model in which social motivation is restructured toward similarity-dependent engagement rather than diminished.

Indexed as

autism spectrum disorderempathyhippocampusposterior cingulate cortexsimilarity attraction

Identifiers

PMID41994137
PMCPMC13082153

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.