ArticleResearch square2026
A finite element computational framework coupling four-chamber heart mechanics with the systemic and pulmonary circulations.
Article in Research square, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 authors.
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Abstract
We present a computational four-chamber heart modeling framework that integrates a 3D finite element (FE) model of heart mechanics with a 0D model of the systemic and pulmonary circulations in a closed-loop system. The computational framework incorporates patient-specific geometry, rule-based myocardial fiber architecture, and nonlinear transversely isotropic tissue mechanics to simulate the full cardiac cycle. A bidirectional 3D-0D coupling strategy together with physiologic epicardial boundary conditions enables stable beat-to-beat simulations. Built on the open-source FEniCS platform with a residual-based stabilized mixed (P1-P1) FE formulation, the computational framework is able to produce pressure-volume loops of the four chambers and myocardial strain waveforms that are comparable to those measured in healthy humans. The framework is used to simulate inter-ventricular interactions arising from a reduction in contractility of the left ventricle (LV) and right ventricle (RV). A reduction in LV contractility produces a 4.9% decrease in RV peak pressure whereas a reduction in RV contractility produces a 20% decrease in LV peak pressure. The framework sets the foundation for patient-specific whole-heart simulations of cardiovascular diseases and treatments in future work.
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