ArticleJournal of dentistry (Shiraz, Iran)2026
Chondroblastic Osteosarcoma of the Palate: A Rare Case Report with Diagnostic Considerations.
Article in Journal of dentistry (Shiraz, Iran), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Osteosarcoma is a rare and highly malignant primary bone tumor that infrequently occurs in the maxillofacial region. Among these, maxillary osteosarcomas are uncommon, and their occurrence in the palatal region is exceptionally rare, with fewer than five cases reported to date. Chondroblastic osteosarcoma, a subtype characterized by cartilaginous and osteoid components, poses diagnostic challenges due to its histological similarities with other cartilaginous tumors. This study presents a 35-year-old female referred to the Department of Oral and Maxillofacial Surgery at Isfahan University of Medical Sciences with a one-month history of palatal pain and swelling which worsened during eating. Clinical examination revealed a firm, ulcerated mass on the right side of the hard palate, clinically mimicking oral squamous cell carcinoma or salivary gland neoplasms. Radiographic evaluation using cone-beam computed tomography (CBCT) revealed an ill-defined, mixed-density lesion with a moth-eaten appearance, cortical bone destruction, and root resorption of adjacent teeth- features suggestive of an aggressive malignancy. Histopathological examination confirmed the diagnosis of chondroblastic osteosarcoma, a rare histologic subtype characterized by malignant cells producing both osteoid and cartilaginous matrix. Given its resemblance to other cartilaginous tumors, particularly chondrosarcoma, this subtype presents significant diagnostic challenges. The patient underwent hemimaxillectomy, followed by adjuvant chemotherapy. Intraoperative frozen section pathology was used to confirm tumor-free surgical margins- an essential step in reducing recurrence risk. This case underscores the importance of a multidisciplinary approach in the diagnosis and management of rare craniofacial malignancies such as chondroblastic osteosarcoma. Early recognition, accurate diagnosis, and prompt aggressive treatment are crucial for improving patient prognosis and reducing recurrence in such complex and rare presentations.
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