ArticleESMO gastrointestinal oncology2026
Real-world treatment outcomes for pancreatic neuroendocrine tumours: a single tertiary referral institute experience.
Article in ESMO gastrointestinal oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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10 authors.
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Abstract
Background: Pancreatic neuroendocrine tumours (PNETs) are rare neoplasms of the pancreas. Real-world treatment outcomes in Asia are seldom reported. The aim of this study was to provide the real-world treatment outcomes of PNETs at a single tertiary cancer centre in Hong Kong over an 18-year period. Materials and methods: This was a retrospective cohort study that recruits patients with local or metastatic PNETs treated at Prince of Wales Hospital, Hong Kong between 2005 and 2023. Five-year overall survival (OS), progression-free survival (PFS), recurrence-free survival (RFS) of the surgical cohort, and survival outcomes in patients with metastatic disease were summarized. Results: A total of 98 patients were recruited (median age: 59 years, 51% male). Among them, 18 patients (18.4%) had functioning tumours, of which majority were insulinoma (72.2%). Most tumours (64.8%) were classified as grade 1 disease. More than 80% of patients had early-stage disease on presentation, with only 14 patients presented with stage IV disease. Five-year OS for the entire cohort was 88.4% and the 5-year PFS was 73.7%. Older age [hazard ratio (HR) 1.06, 95% confidence interval (CI) 1.00-1.13, Conclusion: Patients with PNETs in Hong Kong have early presentation and excellent prognosis with most patients being eligible for curative surgery reaching 90% of 5-year OS.
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