ArticleFrontiers in allergy2026
Concordance between different methods of detecting fungal-specific IgE antibody in asthma.
Article in Frontiers in allergy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Documenting fungal sensitization plays a pivotal diagnostic role in asthma endotypes. Diagnosis relies heavily on detecting fungal-specific immunoglobulin E (sIgE), yet variability in allergen representation, cross-reactivity, and assay performance complicates standardization. Although ImmunoCAP is regarded as the reference method, many commercial kits are available worldwide, with varying accuracy. A scoping review was conducted using Arksey and O'Malley's five-stage framework. Literature searches in PubMed, Scopus, and ProQuest MEDLINE identified studies comparing fungal sIgE detection kits. Inclusion criteria required human studies evaluating fungal allergens in asthma-related diseases. Data from 16 eligible studies and 32 diagnostic kits were analyzed, focusing on assay characteristics, concordance, sensitivity, and specificity. There are 32 commercial kits available, which vary in detection principles, including enzyme immunoassays, immunoblots, and microarrays, with positivity thresholds ranging from 0.1 to 0.35 kUA/L. Most assays identified
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