Evidence map›Paper›PMID 41993920›Full record

ArticleBiological psychiatry global open science2026

Reward-Related Brain Function as an Endophenotype in the Mood-Psychosis Spectrum.

Marjolein E A Barendse, Robert M Bilder, Anne L Snijders, Marit I Broer, Laura J van den Brink-Steinmann, Lingyu Zhan, Alexandria Evans, Annabel Vreeker, Roel A Ophoff, Neeltje E M van Haren

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Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. MIDnight for the Monetary Incentive Delay Task as an Endophenotype?Biological psychiatry global open science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Marjolein E A BarendseDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Robert M BilderSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Anne L SnijdersDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Marit I BroerDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Laura J van den Brink-SteinmannDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Lingyu ZhanSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Alexandria EvansSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Annabel VreekerDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.
Roel A OphoffSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California.
Neeltje E M van HarenDepartment of Child and Adolescent Psychiatry/Psychology, Erasmus University Medical Centre Rotterdam, Rotterdam, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Function of the striatal reward system has been implicated in both psychotic and bipolar disorders. We aimed to test whether ventral striatum (VS) activation during reward anticipation meets criteria of an endophenotype of these disorders. We hypothesized VS activation to be lower in patients than control participants, with nonaffected relatives in between. We also expected negative associations of VS activation with polygenic risk scores (PRSs) and with depressive and negative psychotic symptoms. Methods: One hundred twenty-seven patients, 66 control participants, and 51 first-degree relatives completed the monetary incentive delay task during functional magnetic resonance imaging. Diagnoses were confirmed with clinical interviewing, and PRSs for schizophrenia, bipolar disorder, and major depressive disorder were calculated from DNA testing of whole blood. Neural activation in the VS during reward anticipation was the main outcome. Linear mixed effects models tested 1) group differences (patients, relatives, control participants), 2) effects of manic, depressive, and positive and negative psychotic symptoms (accounting for group for depressive symptoms), and 3) effects of PRSs. Results: Groups did not differ significantly in VS activation during reward anticipation. Current symptom levels were not significantly related to VS activation, nor was there an interaction with group. PRSs were not significantly associated with VS activation. Findings were consistent after controlling for substance use and medication use. Conclusions: We did not find evidence that VS activation during reward anticipation meets criteria of an endophenotype of bipolar and psychotic disorders. Future research should examine associations between neural activation and symptom levels across diagnostic boundaries in a more symptomatic sample.

Indexed as

BipolarFamilial riskfMRIPolygenic riskPsychosisReward

Identifiers

PMID41993920
PMCPMC13080669

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.