ReviewFrontiers in pediatrics2026
Prevalence and risk factors for neonatal sepsis among very preterm infants in China: a systematic review and meta-analysis.
Review in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Maternal obesity and the risk of neonatal sepsis: a meta-analysis.Frontiers in pediatrics · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Neonatal sepsis poses a significant risk to very preterm infants (VPIs, gestational age < 32 weeks) in China, with limited nationwide data on its incidence and risk factors. This study aimed to address this gap through a systematic review and meta-analysis to inform prevention strategies. Methods: We searched PubMed, Embase, Web of Science, Scopus, CNKI, CBM, CSTJ, and WanFang up to March 31, 2025. Study quality was evaluated using the Newcastle-Ottawa Scale (NOS). Data extraction was performed with Microsoft Excel, and Stata 18.0 was used for meta-analysis. Heterogeneity was assessed using Cochran's Results: This systematic review encompassed 43 studies involving a total of 138,613 VPIs. The incidence of unclassified sepsis was determined to be 16.41% (95% CI: 11.80%-21.62%), while the incidence rates for early-onset sepsis (EOS) and late-onset sepsis (LOS) were 16.11% (95% CI: 9.52%-24.01%) and 15.10% (95% CI: 12.07%-18.40%), respectively. The study identified six significant risk factors for EOS among VPIs: lower gestational age [Hedges' Conclusions: Sepsis imposes a substantial burden on Chinese VPIs, characterized by a highly heterogeneous incidence. The principal risk factors for EOS include lower gestational age, lower birth weight, chorioamnionitis, PROM, antenatal antibiotic administration, and endotracheal intubation. These findings furnish essential evidence for the development of risk prediction models and stratified management strategies for EOS in VPIs. Systematic trial registration: The systematic review and meta-analysis were registered with PROSPERO (ID: CRD420251018993).
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