ArticleComputational and structural biotechnology journal2026
Systems Analysis of miRNA-Mediated Host Regulatory Response in HPV-Associated Cervical Malignancy.
Article in Computational and structural biotechnology journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Persistent high-risk human papillomavirus (HPV) infection, particularly types 16 and 18, is the primary driver of cervical carcinogenesis. These viruses utilize viral oncoproteins to manipulate host gene expression through multiple regulatory mechanisms. Within this landscape, microRNAs (miRNAs) emerge as critical posttranscriptional modulators that contribute to the dysregulation of pathways involved in cellular transformation and tumor progression. In this study, we investigated HPV-associated miRNA dysregulation using HPV-negative (C33A) and HPV-positive (SiHa, HeLa) cervical cancer cell lines, integrating custom microarray profiling with comprehensive systems biology and bioinformatic analyses. Our results identified 42 dysregulated miRNAs, including hsa-miR-125b-5p, hsa-miR-106b-5p, hsa-miR-23b-3p, and hsa-miR-30d-5p, which were significantly down-regulated across all experimental models. Integration of these miRNAs with cervical carcinoma transcriptomic data (GSE151666) revealed that HPV16 and HPV18 distinctly remodel host gene networks to drive malignancy. Network analysis pinpointed specific regulatory hubs, such as
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