ArticleInternational journal of nanomedicine2026
Microwave-Responsive MnFe-Based Molybdenum Disulfide Nanoflowers for Enhanced Thermal-Dynamic-Chemo Synergistic Therapy in Bladder Cancer.
Article in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: The most challenging clinical characteristic of bladder cancer (BC) is its exceptionally high recurrence rate. Recurrence, metastasis and drug resistance remain critical challenges in BC treatment. Microwave dynamic therapy (MWDT) is an emerging antitumor modality; however, its therapeutic efficacy is limited by the hypoxic tumor microenvironment (TME). To address these limitations, we developed a multifunctional nanoplatform (Mn-Fe-Dox-BSA-MoS Methods: Reactive oxygen species (ROS) generation, oxygen production, imaging capability, and microwave/acid-responsive drug release were systematically evaluated. The antitumor efficacy and underlying mechanisms of Mn-Fe-Dox-BSA-MoS Results: The nanoflowers exhibited excellent biosafety and efficient microwave sensitization, producing abundant ROS under MW irradiation. Dual-mode FI/PAI imaging enabled precise visualization of tumor accumulation. Mn/Fe complexes catalyzed H Conclusion: Mn-Fe-Dox-BSA-MoS
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