Correlation of MRI-Derived Apparent Diffusion Coefficient (ADC) Values With Gleason Scores in Prostate Cancer and Quantitative Prostate MRI Reading.

Victoria Y Bird, Krystina Masihy, Juan Varela, Joseph Busch

Abstract read

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Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Prostate Cancer Treatment in the Extreme Apex: Preservation of Continence With Robotic-Assisted MRI-Guided Transurethral Ultrasound Ablation.Cureus · 2026
Article

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5 · Who and what money

Authors and funding

4 authors.

Victoria Y BirdUrology, National Medical Association and Research Group, Gainesville, USA.

Krystina MasihyUrology, National Medical Association and Research Group, Gainesville, USA.

Juan VarelaMedicine, University of Florida College of Medicine, Gainesville, USA.

Joseph BuschRadiology, Busch Center, Alpharetta, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate characterization of prostate cancer (PCa) aggressiveness remains a clinical challenge. While multiparametric MRI (mpMRI) and Prostate Imaging Reporting and Data System (PI-RADS) scoring are widely used, their qualitative nature introduces inter-reader variability. Apparent diffusion coefficient (ADC) values derived from diffusion-weighted imaging (DWI) may provide a more objective biomarker of tumor severity.

methodsWe retrospectively analyzed 181 lesions from 101 patients with biopsy-proven PCa (2019-2025). The lowest or minimum ADC (ADC

resultsMean ADC values showed a progressive decline with increasing Gleason category: 3+3 = 456.5 ± 191 µm

conclusionMRI-derived ADC values inversely correlate with Gleason scores, suggesting their potential as a non-invasive biomarker for PCa aggressiveness. Incorporating ADC values into clinical workflows may enhance biopsy targeting, risk stratification, and treatment planning.

Indexed as

adc valuesapparent diffusion coefficient (adc)investigation on dwi/adc mapmri guided prostate biopsymri prostatemultiparametric prostate mriprostate biopsyprostate cancerquantitative methodstrus-mri fusion biopsy

Identifiers

PMID41993765

DOI10.7759/cureus.106336

PMCPMC13081203

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