ArticleFrontiers in bioengineering and biotechnology2026
Histological and biological evaluation of wheat straw-derived nanocellulose in a rat model of cutaneous wound healing.
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Healing of cutaneous wound is a complex biological process that requires the migration of fibroblasts, production of extracellular matrix (ECM) component, angiogenesis and a highly regulated expression pattern of inflammatory mediators. Owing to the interest in wound dressings based on renewable biomaterials, much attention has been paid to their biocompatibility and sustainability. Within these materials, nanocellulose features the physical and chemical properties to promote important cellular processes for tissue regeneration. Methods: Wheat straw-derived nanocellulose was isolated and its nanostructure and physicochemical properties were characterised using FESEM, XRD, EDX, and FTIR analyses. Results: The extracted nanocellulose exhibited a cellulose I crystalline structure and showed no cytotoxic effects on fibroblasts (p > 0.05). Nanocellulose-conditioned medium significantly enhanced fibroblast migration compared with control conditions (p < 0.001) and upregulated the expression of Conclusion: These results suggest that nanocellulose derived from wheat straw can promote cutaneous wound healing by stimulating fibroblast-mediated matrix synthesis and angiogenesis without resulting in excess inflammatory stimulation. Taken together, the
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