Evidence map›Paper›PMID 41993715›Full record

ArticleFrontiers in bioengineering and biotechnology2026

Development and pre-clinical evaluation of an isosorbide-based pit and fissure sealant achieving low polymerization shrinkage and high biocompatibility.

Ming Zhang, Yinan Cui, Su Yang, Xin Liu, Baiyan Sui, Jiao Sun

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Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Ming Zhang *Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Yinan Cui *Shanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Su YangShanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Xin LiuShanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Baiyan SuiShanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.
Jiao SunShanghai Key Laboratory of Stomatology, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Resin-based sealants (RBSs) are widely used to prevent pit and fissure caries in clinical dentistry. However, their high density of C=C double bonds leads to volumetric shrinkage during photo-polymerization, which may compromise enamel bonding. Additionally, the biosafety of commonly used monomers such as bisphenol A glycerolate dimethacrylate (bis-GMA) and triethylene glycol dimethacrylate (TEGDMA) remains a concern due to potential health risks in adolescent patients. This study aimed to develop a bis-GMA- and TEGDMA-free pit and fissure sealant to address these limitations. Methods: A novel family of isosorbide-derived dental sealants (ISDSs) was developed using a synthesized isosorbide-based matrix, bis(2-(methacryloyloxy)ethyl) disuccinate isosorbide (IBMEDS), and a diluent, bis(2-methylacrylate) isosorbide (IBM). The performance of ISDS was evaluated against the commercial Clinpro™ sealant in terms of polymerization shrinkage, cytotoxicity, physicochemical properties, microleakage resistance, and stability of the sealed area under artificial aging conditions. Results: Compared with Clinpro, ISDS exhibited a 34% reduction in polymerization shrinkage and a more than sevenfold increase in L929 cell viability, attributed to its bio-based structure and low double-bond density. Moreover, ISDS demonstrated superior physicochemical properties, including higher shear bond strength, more effective marginal adaptation to enamel, lower water absorption and solubility, and more sustained and stable long-term fluoride release, while maintaining comparable microleakage resistance. Conclusion: A fully bio-based, fluoride-containing isosorbide-derived dental sealant (ISDS) was developed to overcome the polymerization shrinkage and biocompatibility limitations of conventional resin-based sealants. This novel sealant offers enhanced long-term stability, excellent biocompatibility, improved marginal adaptation, and sustained fluoride release, representing a safer and more effective alternative for caries prevention in children and adolescents.

Indexed as

bio-based sealantbiocompatibilitycaries preventionisosorbidepolymerization shrinkage

Identifiers

PMID41993715
PMCPMC13079693

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.