ArticleClinical kidney journal2026
The percentage of normal glomeruli ("Normal" Glomerular Score) predicts kidney outcome in ANCA vasculitis.
Article in Clinical kidney journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Comparative Performance of the ANCLA Risk Score and Established Prognostic Models for Predicting ESKD in ANCA-Associated Glomerulonephritis: A Latin American Cohort.International journal of nephrology · 2026Article
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7 authors.
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Abstract
Background: In the management of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), accurate prognostication of renal outcome is critical. However, the clinical utility of highly precise multi-variable models, such as the ANCA Kidney Risk Score (AKRiS), is often hampered by their complexity. This study aimed to validate a simple alternative: the "Normal" Glomerular Score (NGS), defined as the percentage of normal glomeruli. Methods: We retrospectively analyzed 188 consecutive patients with biopsy-proven AAV-glomerulonephritis (GN) from a single European center (2001-24). Patients were categorized by NGS: high (>50%), moderate (26%-50%), low (10%-25%) and very low (<10%). We assessed concordance between NGS, Berden classification and AKRiS to determine whether NGS serves as a valid proxy for complex systems. The primary endpoint was death-censored progression to end-stage kidney disease. Results: The NGS strongly indicated presentation renal function; median estimated glomerular filtration rate (eGFR) was 31.4 mL/min in the high NGS group vs 10.8 mL/min in the low cohort ( Conclusion: NGS predicts long-term renal survival in AAV-GN. While not replacing multi-variable models like AKRiS for precise risk assessment in clinical trials, it offers a rapid, accessible estimation of functional nephron mass for bedside stratification.
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