Evidence map›Paper›PMID 41993632›Full record

ArticleTheranostics2026

ELAPOR1 regulates VPS54-mediated GARP complex formation and proacrosomal vesicle fusion during spermatogenesis.

Chen Ding, Tingting Liang, Mina Yang, Lingbin Wang, Xuying Yin, Guoming Li, Zhaoxiang Wang, Jiahui Guo, Lin Zhang, Jie Yang and 4 more

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In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Chen DingDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tingting LiangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Mina YangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lingbin WangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xuying YinDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guoming LiDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhaoxiang WangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jiahui GuoDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin ZhangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Jie YangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xiaoyu XiaDepartment of Histo-Embryology, Genetics and Developmental Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yanyan XuDepartment of Laboratory Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junling LiuDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Haojie JiangDepartment of Biochemistry and Molecular Cell Biology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rationale: Acrosomal developmental defects are associated with severe sperm morphogenetic abnormalities and male infertility; however, the specific molecular determinants underlying these defects remain poorly defined. Endosome/lysosome-associated apoptosis and autophagy regulator 1 (ELAPOR1) is important for cellular membrane dynamics and organelle functions, indicating that it plays an essential role in spermatogenesis, which needs further investigation. This study aimed to explore the specific role of ELAPOR1 in spermatogenesis and male fertility. Methods: Single-cell RNA-sequencing datasets from human testes were obtained to investigate the expression of Results: ELAPOR1 is highly expressed and its protein colocalized with the acrosome during the early stage of acrosome formation. Conclusions: Our findings reveal the essential role of ELAPOR1 in acrosome formation during spermatogenesis and male fertility. ELAPOR1 potentially influences the trafficking, integration, and fusion of proacrosomal vesicles through VPS54-mediated GARP complex assembly. These findings provide novel insights into the interaction of the ELAPOR1-GARP complex in acrosome-related reproductive failure, suggesting that

Indexed as

AcrosomeApoptosis Regulatory ProteinsSpermatogenesisVesicular Transport ProteinsAnimalsHumansInfertility, MaleMaleMiceMice, KnockoutSpermatozoaTestisApoptosis Regulatory ProteinsVesicular Transport ProteinsacrosomeELAPOR1globozoospermiainfertilityspermatogenesis

Identifiers

PMID41993632
PMCPMC13080796

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.