ArticleTheranostics2026
Engineering inertial flow patterns for signal amplification in disc-based protein assays.
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Detecting low-abundance proteins is essential in liquid biopsy applications, particularly for extracellular vesicle (EV)-based diagnostics. Here, we introduce RapidEx ( Methods: The device leverages a unique interplay between disc-specific inertial forces (centrifugal and Coriolis) and membrane-filter flow dynamics. Unlike conventional systems, RapidEx utilizes a low-permeability membrane to redirect fluid laterally during rotation, thereby enhancing washing efficiency and signal-to-noise ratio. The performance of the device was validated through numerical simulation and tyramide-mediated amplification assays. This system processed plasma samples from patients with ovarian cancer ( Results: Numerical simulations and experimental validations confirmed that Coriolis-induced lateral flows were found critical to improving labeling and washing efficiency. This synergetic fluidic control with enzymatic chemical reaction enhanced the signal-to-noise ratio, which is >25-fold more sensitive than standard two-step labelling. Applying this platform to clinical samples, protein profiles enabled differentiation between cancer patients and controls and allowed for the identification of platinum therapy resistance in patients prior to chemotherapy treatment. Conclusions: RapidEx could enable rapid and cost-effective protein-based liquid biopsies, with applications in disease detection and monitoring therapeutic responses.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.