ArticleTheranostics2026
Near-infrared light-activated lidocaine microneedle patch for rapid local anesthesia.
Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rationale: Effective local anesthesia with rapid onset and minimal invasiveness is essential for certain minor surgeries, such as aesthetic procedures, but remains difficult to achieve with conventional local anesthesia. Methods: A photothermal-responsive microneedle system (LiH/MXene@MNs) was developed, consisting of lidocaine-loaded needle tips and a backing layer in which MXene was confined exclusively. This system employs a spatial design that separates the drug and photothermal components, allowing efficient drug delivery under short-term near-infrared (NIR) irradiation. Mechanical, optical, and histological assessments were performed to evaluate the system's properties. Results: The LiH/MXene@MNs system exhibited robust skin penetration and high drug-loading efficiency. Behavioral tests in a rat plantar incision model further verified that anesthesia onset was induced within 5 minutes and sustained for up to 60 minutes on this platform, comparable to that achieved with invasive injection. Additionally, the system exhibited minimal invasiveness and excellent biosafety, as demonstrated by both Conclusions: The LiH/MXene@MNs platform offers an efficient, minimally invasive, and safe alternative to traditional local anesthesia techniques. This approach holds strong potential for use in minimally invasive aesthetic procedures, providing a promising solution for rapid and effective pain management.
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