Evidence map›Paper›PMID 41993622›Full record

ArticleTheranostics2026

Host-directed nanotherapy for the treatment and imaging of tuberculous meningitis.

Elizabeth W Tucker, John Kim, Clara Erice, Anjali Sharma, Nerketa N L Damiba, Alvaro A Ordonez, Javier Allende Labastida, Nirnath Sah, Filipa Mota, Patricia de Jesus and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Elizabeth W TuckerCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
John KimCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Clara EriceCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Anjali SharmaCenter for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Nerketa N L DamibaCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Alvaro A OrdonezCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Javier Allende LabastidaDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Nirnath SahCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Filipa MotaCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Patricia de JesusCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Rhea SainiDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Kelly F SchiaffinoCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sanjay K JainCenter for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Rangaramanujam M KannanCenter for Nanomedicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Sujatha KannanDepartment of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.

Funding

Novel Imaging and host-directed therapy in pediatric CNS TBK08AI139371 · NIAID · JOHNS HOPKINS UNIVERSITY · PI TUCKER, ELIZABETH WINANS · 2019 to 2023
$994k
NIAID NIH HHS K08 AI139371
6 · The paper itself

Abstract

Rationale: Tuberculous meningitis (TB meningitis) is a devastating infection where the host immune response drives brain injury. Standard adjunctive corticosteroids often fail to prevent neurological sequelae or improve survival in many populations. Host-directed therapies that can cross the blood-brain barrier (BBB) and reduce neuroinflammation are urgently needed. We evaluated a hydroxyl-terminated polyamidoamine (PAMAM) dendrimer as a theranostic nanoplatform to visualize and treat microglia-mediated neuroinflammation in a young rabbit model of TB meningitis. Methods: A novel radiolabeled dendrimer ( Results: Conclusions: This study establishes D-NAC as a promising host-directed theranostic strategy for TB meningitis and supports the clinical potential of dendrimer nanoplatforms to diagnose and treat central nervous system infections.

Indexed as

Theranostic NanomedicineTuberculosis, MeningealAnimalsBlood-Brain BarrierBrainDendrimersDisease Models, AnimalHost-Directed TherapyIodine RadioisotopesMicrogliaPositron-Emission TomographyRabbitsDendrimersIodine RadioisotopesPAMAM Starburstdendrimerhost-directed therapymicrogliaPET imagingtuberculous meningitis

Identifiers

PMID41993622
PMCPMC13080335

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.