ArticleFrontiers in pharmacology2026
Oral contraceptives exposure may reduce the risk of ovarian cancer: a meta-analysis based on cohort studies.
Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Ovarian cancer ranks fourth in terms of incidence among gynecological malignancies and third as a cause of cancer death in the gynecological field, with oral contraceptives (OCs) exhibiting a potential relationship to ovarian cancer chemoprevention. This meta-analysis aimed to investigate the association between exposure to OCs and the incidence of ovarian cancer. Methods: Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, PubMed, Web of Science, Embase, and the Cochrane Library were searched for cohort studies on OCs and ovarian cancer incidence, covering the period from the establishment of each database to May 2025. Hazard ratio (HR) and 95% confidence interval (95% CI) were applied to assess the association between OCs and ovarian cancer incidence, with subgroup analyses performed for duration of use, time since OCs discontinuation, and geographical region. Results: This meta-analysis included a total of 11 cohort studies. The results revealed that the OCs exposure group had a significantly lower ovarian cancer incidence than the control group (HR: 0.80, 95% CI: 0.71-0.89; P < 0.001; I Conclusion: This study demonstrated that OCs exposure can exert a preventive effect on ovarian cancer, but such prevention necessitates a duration of use of more than 5 years, and the effect is impacted by geographical factors. In the future, OCs may emerge as one of the potential measures for ovarian cancer prevention.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.