A basophil-specific GPCR mediates the immune response to helminth infection.

Aleksander Geske, Rachel Pan, Celeste Flores, Taylor Follansbee, Nathachit Limjunyawong, Xintong Dong, Xinzhong Dong

Abstract readPreprint

In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Aleksander GeskeThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Rachel PanThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Celeste FloresThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Taylor FollansbeeThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Nathachit LimjunyawongThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Xintong DongDepartment of Biological Sciences, University of Texas at Dallas, Richardson, TX 75080, USA.

Xinzhong DongThe Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

Funding

Functional Analysis of Mrgpr Family in itch sensationR37NS054791 · NINDS · JOHNS HOPKINS UNIVERSITY · PI Xinzhong Dong · 2022 to 2026

$2.9M

NINDS NIH HHS R37 NS054791

6 · The paper itself

Abstract

Basophils are rare innate immune cells that contribute to type 2 immunity in allergy and parasitic helminth infection, yet the receptors governing their activation remain poorly defined. Here, we identify the G protein-coupled receptor (GPCR) Mrgpra6 as a basophil-specific gene that mediates the host response to helminth infection. Mrgpra6 expression is restricted to basophils in blood and lung and is uniformly expressed across the population. Knockout of Mrgpra6 impairs early innate immunity to invading helminths, resulting in increased larval burden, elevated mortality, and disrupted parasite progression within the host. Transcriptional profiling of FACS-sorted basophils during helminth infection reveals how Mrgpra6 shapes the basophil transcriptional landscape needed for effective host defense. Together, these findings identify Mrgpra6 as a functional regulator of basophil-mediated anti-helminth immunity.

Identifiers

PMID41993543

DOI10.64898/2026.04.06.716327

PMCPMC13081893

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.