Evidence map›Paper›PMID 41993529›Full record

ArticlebioRxiv : the preprint server for biology2026

AT2-intrinsic Z-AAT expression drives conserved inflammatory and proteotoxic stress responses and predisposes to emphysema.

Carly Merritt, Rose P Griffin, Kristine M Abo, Joseph E Kaserman, Pushpinder Singh Bawa, Carlos Villacorta Martin, Feiya Wang, Michael Morley, Michael Cho, Maria C Basil and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Carly MerrittCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.ORCID 0000-0002-9470-6607
Rose P GriffinCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Kristine M AboCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Joseph E KasermanCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Pushpinder Singh BawaCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Carlos Villacorta MartinCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Feiya WangCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.
Michael MorleyDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Michael ChoChanning Division of Network Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA.ORCID 0000-0002-4907-1657
Maria C BasilDepartment of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Penn-CHOP Lung Biology Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
Maor SaulerPulmonary, Critical Care, and Sleep Medicine, Yale School of Medicine, New Haven, CT.
Andrew A WilsonCenter for Regenerative Medicine of Boston University and Boston Medical Center, Boston, MA; The Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, MA.

Funding

Project-005UL1TR001430 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BAIR-MERRITT, MEGAN H, CENTER, DAVID M. · 2015 to 2024
$52.3M
BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
Patient-specific iPSCs to model and treat the inception of pulmonary fibrosisP01HL170952 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton · 2024 to 2026
$11.4M
Scientific Human Biomarker Exposure Monitoring Core (HEMC) for the Air pollution disrupts Inflammasome Regulation in HEart And Lung Total Health (AIRHEALTH) StudyP01HL152953 · NHLBI · STANFORD UNIVERSITY · PI DESAI, MANISHA · 2021 to 2025
$9.8M
A National iPS Cell Network with Deep Phenotyping for Translational ResearchU01TR001810 · NCATS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI GILAD, YOAV, KOTTON, DARRELL N. · 2016 to 2020
$4.4M
Mechanistic studies of the genetic contribution of desmoplakin to pulmonary fibrosis in alveolar type 2 cellsR01HL166407 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI ANDREW A WILSON, Anny Xiaobo Zhou · 2023 to 2026
$3.1M
Mechanisms of Metabolic Dysregulation in ZZ Alpha-1 Antitrypsin Deficiency Associated Liver DiseaseK08DK140640 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Joseph Emery Kaserman · 2025 to 2026
$334k
Gain-of-function toxicity in alpha-1 antitrypsin deficient type 2 alveolar epithelial cellsF30HL170745 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Carly Merritt · 2023 to 2026
$162k
NCATS NIH HHS U01 TR001810NCATS NIH HHS UL1 TR001430NHLBI NIH HHS F30 HL170745NHLBI NIH HHS P01 HL152953NHLBI NIH HHS P01 HL170952NHLBI NIH HHS R01 HL166407NHLBI NIH HHS T32 HL007035NIDDK NIH HHS K08 DK140640
6 · The paper itself

Abstract

Individuals homozygous for the

Identifiers

PMID41993529
PMCPMC13082089

What OpenQuestion holds

Textmetadata
LicenceCC0
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.