Evidence map›Paper›PMID 41993525›Full record

ArticlebioRxiv : the preprint server for biology2026

Neuron-specific epigenetic repression of

Kiara L Rodríguez-Acevedo, Julia J Winter, Megan I Alvarez, Ajinkya Sase, Kyle Czarnecki, Elizabeth A Heller

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Kiara L Rodríguez-AcevedoDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-7839-771X
Julia J WinterDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0001-8518-0167
Megan I AlvarezDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Ajinkya SaseDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-9483-0077
Kyle CzarneckiDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.
Elizabeth A HellerDepartment of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania, Philadelphia, PA 19104, USA.ORCID 0000-0002-2984-8705

Funding

Epigenetic mechanisms of sustained transcription across cocaine abstinenceR01DA052465 · NIDA · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2021 to 2026
$4.0M
Epigenetic regulation of Cdk5 in cognition and emotionR01MH126027 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI Elizabeth A Heller · 2023 to 2026
$2.2M
NIDA NIH HHS R01 DA052465NIMH NIH HHS R01 MH126027
6 · The paper itself

Abstract

Biological sex regulates fundamental neurobiology, as well as the etiology and prevalence of neuropsychiatric disorders. Cyclin-dependent kinase 5 (Cdk5) is a neuronally enriched kinase that regulates synaptic plasticity, neuronal homeostasis, and hippocampal-dependent memory. While Cdk5 protein activity is necessary and sufficient to promote memory in male rodents, its role in females and its gene regulation in either sex remain poorly understood. In males, Cdk5 protein inhibition impairs fear memory. We previously showed that fear conditioning activates

Identifiers

PMID41993525
PMCPMC13082083

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.