Evidence map›Paper›PMID 41993513›Full record

ArticlebioRxiv : the preprint server for biology2026

A previously unappreciated class of metal-dependent bile salt hydrolases from the human gut microbiome.

Zheng Cui, Christopher J Meng, Stephania M Irwin, Hannah E Augustijn, Panagiotis Panagopoulos Papageorgiou, Anh T P Nguyen, Ruocheng Yu, Miguel A Aguilar Ramos, Heather J Kulik, Emily P Balskus

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zheng CuiDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Christopher J MengDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Stephania M IrwinDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Hannah E AugustijnDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Panagiotis Panagopoulos PapageorgiouDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Anh T P NguyenDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Ruocheng YuDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Miguel A Aguilar RamosDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.
Heather J KulikDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.
Emily P BalskusDepartment of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA.

Funding

TOXICOLOGY CORE UNITP30ES002109 · NIEHS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI NILES, JACQUIN C · 1985 to 2020
$25.6M
Revealing Nature's Blueprints for Single-Site Catalysis of C-H Activation with First-principles Modeling and Machine LearningR35GM152027 · NIGMS · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Heather J. Kulik · 2024 to 2026
$1.2M
Natural product discovery and biosynthetic pathway elucidation from the human pathogen LegionellaF32GM151795 · NIGMS · HARVARD UNIVERSITY · PI CUI, ZHENG · 2023 to 2024
$165k
NIEHS NIH HHS P30 ES002109NIGMS NIH HHS F32 GM151795NIGMS NIH HHS R35 GM152027
6 · The paper itself

Abstract

Bile salt hydrolases (BSHs) are gut microbial enzymes that catalyze the deconjugation of glycine- or taurine-conjugated bile acids (BAs), a key step in shaping the BA pool in the human gastrointestinal tract and modulating host-gut microbiome interactions.

Identifiers

PMID41993513
PMCPMC13081902

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.