Evidence map›Paper›PMID 41993512›Full record

ArticlebioRxiv : the preprint server for biology2026

WDR44 drives de novo α-synuclein aggregation at the lysosomal membrane and promotes neuronal dysfunction in Parkinson's Disease.

Maxime Teixeira, Razan Sheta, Morgan Bérard, Christine Insinna, Anne-Laure Mahul-Mellier, Constantin V L Delmas, Eva Lépinay, Walid Idi, Alexandra Ricard, Esther Del Cid-Pellitero and 14 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Maxime TeixeiraCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Razan ShetaCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Morgan BérardCERVO Brain Research Center and Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.
Christine InsinnaLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Anne-Laure Mahul-MellierLaboratory of Molecular and Chemical Biology of Neurodegeneration, Brain Mind Institute, Ecole Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland.
Constantin V L DelmasCERVO Brain Research Center and Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.
Eva LépinayCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Walid IdiCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Alexandra RicardCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Esther Del Cid-PelliteroNeurodegenerative Disorders Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital (The Neuro), McGill University, Montreal, QC H3A 2B4, Canada.
Christine TrabolsiCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Stéphane GobeilCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Marie-Hélène CanronUniversity of Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
Erwan BézardUniversity of Bordeaux, CNRS, IMN, UMR 5293, F-33000, Bordeaux, France.
Alex RajputMovement Disorders Program, Division of Neurology, University of Saskatchewan and Saskatchewan Health Authority, Saskatoon, SK, Canada.
Francesca CicchettiCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Martin ParentCERVO Brain Research Center and Department of Psychiatry and Neuroscience, Faculty of Medicine, Université Laval, Quebec City, QC G1V 0A6, Canada.ORCID 0000-0002-0868-1010
Edward A FonNeurodegenerative Disorders Research Group, Department of Neurology and Neurosurgery, Montreal Neurological Institute-Hospital (The Neuro), McGill University, Montreal, QC H3A 2B4, Canada.ORCID 0000-0002-5520-6239
Nagendran RamalingamAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Ulf DettmerAnn Romney Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115, USA.
Frederic CalonCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.
Christopher WestlakeLaboratory of Cell and Developmental Signaling, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Frederick, MD, USA.
Hilal A LashuelWeill Cornell Medicine Qatar, Education City, Qatar Foundation, Doha, Qatar.
Abid OueslatiCHU de Québec Research Center, Axe Neurosciences, Quebec City, QC, Canada.ORCID 0000-0003-1122-7086

Funding

How Serine-129 Phosphorylation Status Affects the Spreading of α-Synuclein Pathology in Vivo: a Study in Knock-in AnimalsRF1NS133979 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI DETTMER, ULF, RAMALINGAM, NAGENDRAN · 2023 to 2023
$2.2M
Stabilizing native α-synuclein homeostasis to prevent insoluble α-synuclein aggregatesR01NS099328 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI DETTMER, ULF · 2017 to 2021
$1.9M
How Serine-129 Phosphorylation Status Affects the Spreading of α-Synuclein Pathology in Vivo: a Study in Knock-in AnimalsR01NS133979 · NINDS · BRIGHAM AND WOMEN'S HOSPITAL · PI Ulf Dettmer, Nagendran Ramalingam · 2026 to 2026
$724k
Distinguishing α-Synuclein S129 Phosphorylation in Health and Lewy Body DementiaR21AG085401 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI Nagendran Ramalingam · 2024 to 2026
$433k
NIA NIH HHS R21 AG085401NINDS NIH HHS R01 NS099328NINDS NIH HHS R01 NS133979NINDS NIH HHS RF1 NS133979
6 · The paper itself

Abstract

The aggregation of α-synuclein (α-SYN) into Lewy bodies (LBs) is a central event in the pathogenesis of Parkinson's disease (PD) and related synucleinopathies

Identifiers

PMID41993512
PMCPMC13081842

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.