Evidence map›Paper›PMID 41993508›Full record

ArticlebioRxiv : the preprint server for biology2026

Insulinoma-associated 1 promotes neurogenic proliferation of cortical basal progenitors but is largely dispensable for projection neuron production.

Venkata Thulabandu, Xinwei Cao

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Venkata ThulabanduDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
Xinwei CaoDepartment of Developmental Neurobiology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.ORCID 0000-0003-0651-5243

Funding

Viral Vector Technology (VVTSR)P30CA021765 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Shondra Michelle Miller · 1985 to 2026
$166.9M
Understanding the developmental progression of subpallial neural progenitor cellsR01NS119760 · NINDS · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI CAO, XINWEI · 2021 to 2024
$1.8M
NCI NIH HHS P30 CA021765NINDS NIH HHS R01 NS119760
6 · The paper itself

Abstract

Basal progenitors (BPs) are essential contributors to mammalian cortical neurogenesis, yet the mechanisms governing their behavior remain incompletely understood. Insulinoma-associated 1 (INSM1), a SNAG-domain zinc-finger transcription factor, has been proposed to promote BP generation and expansion, although prior conclusions relied heavily on gain-of-function approaches and were limited by early lethality of

Identifiers

PMID41993508
PMCPMC13082098

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.