ArticlebioRxiv : the preprint server for biology2026
Concordant transcriptional and morphological remodeling revealed by
Boli Wu, Sean K Simmons, Seoyeon Kim, Jiwen Li, Masood A Akram, Chang Sin Park, Xinhe Zheng, Iain Mendez, Sasha Patel, Alan Chau and 8 more
Abstract readPreprint
In one paragraphArticle in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
18 authors.
Sean K SimmonsStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
Seoyeon KimHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Masood A AkramCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-7178-6974 Chang Sin ParkCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0002-8851-7236 Iain MendezHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Sasha PatelHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Alan ChauHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Nadia BurciuHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Pranay DayalHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Thokozile NyasuluHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Nhan HuynhHoward Hughes Medical Institute, Chevy Chase, MD, USA.
Grace S ClarkeHoward Hughes Medical Institute, Chevy Chase, MD, USA.
X William YangCenter for Neurobehavioral Genetics, Jane and Terry Semel Institute of Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, CA, USA.ORCID 0000-0003-3705-7935 Joshua Z LevinStanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-0170-3598 Funding
Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2MBuilding a somatosensory atlas for interoceptionR01AT013748 · NCCIH · SCRIPPS RESEARCH INSTITUTE, THE · PI Ardem Patapoutian, Bosiljka Tasic · 2025 to 2026
$5.7MNext-generation MORF Mice for Scalable Brainwide Morphological Mapping and Genetic Perturbation of Single NeuronsRF1MH128888 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONG, HONG-WEI, YANG, XIANGDONG WILLIAM · 2021 to 2021
$4.4MDendritome mapping of genetically-defined and sparsely-labeled cortical and striatal projection neuronsU01MH117079 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DONG, HONG-WEI, YANG, XIANGDONG WILLIAM · 2018 to 2022
$4.3MIn vivo Perturb-map: scalable genetic screens with single-cell and spatial resolution in intact tissuesR01HG012819 · NHGRI · SCRIPPS RESEARCH INSTITUTE, THE · PI Xin Jin · 2023 to 2026
$3.0MScalable functional analysis of neuropsychiatric risk genes with spatially integrated in vivo Perturb-seqR01MH137042 · NIMH · SCRIPPS RESEARCH INSTITUTE, THE · PI Xin Jin, Joshua Zvi Levin · 2024 to 2026
$2.7MBeckman Coulter Biomek i7 Hybrid automated workstationS10OD036254 · OD · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI HUANG, CHUN-TENG · 2024 to 2024
$594kNCCIH NIH HHS R01 AT013748NCI NIH HHS P30 CA030199NHGRI NIH HHS R01 HG012819NIH HHS S10 OD036254NIMH NIH HHS R01 MH137042NIMH NIH HHS RF1 MH128888NIMH NIH HHS U01 MH117079
6 · The paper itselfAbstract
The principle that form follows function has long guided thinking in biology and architecture alike. In the nervous system, however, form does more than reflect function: neuronal morphology actively constrains input patterns, synaptic integration, and circuit wiring. During postnatal neurodevelopment, dendritic architectures are assembled and remodeled through genetically encoded programs and activities, transforming molecular programs into circuit architecture. However, dendritic morphogenesis has been difficult to quantify at scale while systematically testing how genetic variants, including neurodevelopmental disorder (NDD) risk genes, alter these structures
Identifiers
PMID41993505
PMCPMC13081986
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