Evidence map›Paper›PMID 41993500›Full record

ArticlebioRxiv : the preprint server for biology2026

Molecular architecture of the ciliary base in mammalian multiciliated cells.

Caitlyn L McCafferty, Marine Brunet, Hugo van den Hoek, Garrison Buss, Olivier Mercey, Philippe Van der Stappen, Danilo Ritz, Adrian Müller, Ricardo Righetto, Paul Guichard and 3 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Caitlyn L McCaffertyBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.ORCID 0000-0002-0872-4527
Marine BrunetDepartment of Molecular and Cellular Biology, University of Geneva, Sciences III, Geneva, Switzerland.ORCID 0000-0001-7878-3832
Hugo van den HoekBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.ORCID 0000-0003-4978-8516
Garrison BussDepartment of Biology, Stanford University, Stanford, USA.
Olivier MerceyDepartment of Molecular and Cellular Biology, University of Geneva, Sciences III, Geneva, Switzerland.
Philippe Van der StappenBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.ORCID 0009-0006-8746-1222
Danilo RitzBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Adrian MüllerBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.
Ricardo RighettoBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.ORCID 0000-0003-4247-4303
Paul GuichardDepartment of Molecular and Cellular Biology, University of Geneva, Sciences III, Geneva, Switzerland.ORCID 0000-0002-0363-1049
Virginie HamelDepartment of Molecular and Cellular Biology, University of Geneva, Sciences III, Geneva, Switzerland.ORCID 0000-0001-5092-2343
Tim StearnsDepartment of Biology, Stanford University, Stanford, USA.
Benjamin D EngelBiozentrum, University of Basel, Spitalstrasse 41, 4056 Basel, Switzerland.ORCID 0000-0002-0941-4387

Funding

Structure and mechanism of the centrosome-cilium complexR35GM130286 · NIGMS · STANFORD UNIVERSITY · PI STEARNS, TIM · 2019 to 2023
$3.4M
NIGMS NIH HHS R35 GM130286
6 · The paper itself

Abstract

Multiciliated epithelial cells (MCCs) generate tens to hundreds of motile cilia to drive fluid flow in diverse physiological contexts. While the axonemal structure of motile cilia has been described extensively in recent years, the molecular architecture of the transition zone, basal body, and surrounding ciliary environment of MCCs remain more elusive. Here, we use cryo-focused ion beam (cryo-FIB) milling and cryo-electron tomography (cryo-ET) to obtain

Identifiers

PMID41993500
PMCPMC13082021

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.