Evidence map›Paper›PMID 41993499›Full record

ArticlebioRxiv : the preprint server for biology2026

Structural principles of transcriptional collisions.

John W Watters, Andreas U Mueller, Xiangwu Ju, Stephany J Chuquimarca, Hannah J Ye, Seth A Darst, Gregory M Alushin, Shixin Liu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

John W WattersLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-5786-8861
Andreas U MuellerLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-3002-3695
Xiangwu JuLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.
Stephany J ChuquimarcaLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-4030-7165
Hannah J YeLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.ORCID 0009-0008-8881-678X
Seth A DarstLaboratory of Molecular Biophysics, The Rockefeller University, New York, NY, USA.ORCID 0000-0002-8241-3153
Gregory M AlushinLaboratory of Structural Biophysics and Mechanobiology, The Rockefeller University, New York, NY, USA.ORCID 0000-0001-7250-4484
Shixin LiuLaboratory of Nanoscale Biophysics and Biochemistry, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-4238-7066

Funding

Genetics and Cell BiologyT32GM066699 · NIGMS · ROCKEFELLER UNIVERSITY · PI STRICKLAND, SIDNEY · 2004 to 2021
$7.6M
Biophysical Determinants of the Nucleosome as an Activity Center for Chromatin RegulatorsR01GM149862 · NIGMS · ROCKEFELLER UNIVERSITY · PI Shixin Liu · 2023 to 2026
$1.4M
Cytoskeletal force-sensing mechanismsR35GM161251 · NIGMS · ROCKEFELLER UNIVERSITY · PI GREGORY M ALUSHIN · 2026 to 2026
$395k
NIGMS NIH HHS R01 GM149862NIGMS NIH HHS R35 GM161251NIGMS NIH HHS T32 GM066699
6 · The paper itself

Abstract

RNA polymerase (RNAP) must navigate crowded genomic tracks to robustly produce transcripts. DNA-bound proteins act as transcription-impeding roadblocks, which are eventually overcome by RNAPs through unclear mechanisms. Here, we use cryo-electron microscopy to visualize actively transcribing

Identifiers

PMID41993499
PMCPMC13082048

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.