Evidence map›Paper›PMID 41993493›Full record

ArticlebioRxiv : the preprint server for biology2026

Mount Fuji's stubby peak: the genotypic density of additive landscapes near maximal fitness.

Justin B Kinney

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author.

Justin B KinneySimons Center for Quantitative Biology, Cold Spring Harbor Laboratory, 1 Bungtown Rd., Cold Spring Harbor, New York, 11724, United States.ORCID 0000-0003-1897-3778

Funding

A unified quantitative modeling strategy for multiplex assays of variant effectR01HG011787 · NHGRI · COLD SPRING HARBOR LABORATORY · PI JUSTIN B. KINNEY · 2022 to 2026
$4.1M
Graphical Processing Units and a Large-Memory Compute Node for Applications in Genomics, Neuroscience, and Structural BiologyS10OD028632 · OD · COLD SPRING HARBOR LABORATORY · PI SIEPEL, ADAM CHARLES · 2020 to 2020
$437k
NHGRI NIH HHS R01 HG011787NIH HHS S10 OD028632
6 · The paper itself

Abstract

Additive fitness landscapes-also called Mount Fuji landscapes-are the simplest and most widely used models of sequence-function relationships. As such, they play essential roles across multiple areas of biology, including evolutionary theory, quantitative genetics, gene regulation, and protein science. One of the most basic properties of any fitness landscape is its

Indexed as

additive modelsfitness landscapesgenotypic densityglobal epistasissaddle-point approximation

Identifiers

PMID41993493
PMCPMC13081852

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.