Evidence map›Paper›PMID 41993491›Full record

ArticlebioRxiv : the preprint server for biology2026

Redox imbalance dictates dependence on GOT1 versus GOT2 for rod photoreceptor health during aging and stress.

Meini Chen, Eric Weh, Moloy T Goswami, Katherine M Weh, Heather Hager, Peter Sajjakulnukit, Avi Weingarten, Shubha Subramanya, Nicholas Miller, Sraboni Chaudhury and 5 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Meini ChenDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Eric WehDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Moloy T GoswamiDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Katherine M WehDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Heather HagerDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Peter SajjakulnukitDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.
Avi WeingartenDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Shubha SubramanyaDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Nicholas MillerDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Sraboni ChaudhuryDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Emma PirainoDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.
Navdeep S ChandelDepartment of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, IL, United States.ORCID 0000-0001-7208-3886
Renee C RyalsDepartment of Ophthalmology, Casey Eye Institute, Oregon Health & Science University, Portland, OR, United States.
Costas A LyssiotisDepartment of Molecular & Integrative Physiology, University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0001-9309-6141
Thomas J WubbenDepartment of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI, United States.

Funding

Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Scott Soleimanpour · 2013 to 2026
$24.3M
Proteomics CoreP30EY010572 · NEI · OREGON HEALTH & SCIENCE UNIVERSITY · PI John Peter Campbell · 1995 to 2026
$19.4M
VIVARIUM MODULEP30EY007003 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti · 1987 to 2026
$17.6M
Intratumoral Metabolic Crosstalk Promotes Therapeutic Resistance in Pancreatic CancerR37CA237421 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Costas Andreas Lyssiotis · 2020 to 2026
$2.6M
Stromal metabolism promotes therapeutic resistance in pancreatic cancerR01CA248160 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$2.0M
Targeting metabolic stress to induce pancreatic tumor cell deathR01CA244931 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LYSSIOTIS, COSTAS ANDREAS · 2020 to 2024
$1.9M
Glutamine as an alternative fuel source for photoreceptorsK08EY031757 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WUBBEN, THOMAS JOSEPH · 2020 to 2024
$1.2M
NCI NIH HHS R01 CA244931NCI NIH HHS R01 CA248160NCI NIH HHS R37 CA237421NEI NIH HHS K08 EY031757NEI NIH HHS P30 EY007003NEI NIH HHS P30 EY010572NIDDK NIH HHS P30 DK020572
6 · The paper itself

Abstract

Photoreceptor (PR) loss causes vision loss in many blinding diseases, and effective therapies to prevent this cell loss are lacking. Aspartate aminotransferases (GOTs), located in the cytosol (GOT1) and mitochondria (GOT2), are key components of the malate-aspartate shuttle, which transfers reducing equivalents from cytosol to mitochondria. Previous work has implicated the GOTs as potential modulators of blinding retinal disease. To determine the roles of GOT1 and GOT2 in rod PRs, we generated rod PR-specific

Indexed as

GOT1GOT2metabolismneuroprotectionPhotoreceptor

Identifiers

PMID41993491
PMCPMC13081828

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.