Evidence map›Paper›PMID 41993480›Full record

ArticlebioRxiv : the preprint server for biology2026

Lipoengineering of Biomolecular Condensates Controls Material Properties and Multiphase Hierarchy to Guide Organoid Morphogenesis.

Zhiwei Huang, Md Mahbubul Alam, Mahtab Shokri, Harshavardhan C Savitrinarayana, Sisila Valappil, Tanushree Agarwal, Rob M Scrutton, Laiba Maryam, Asma Gulzar, Jinying Wang and 11 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Zhiwei HuangDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Md Mahbubul AlamDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Mahtab ShokriDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Harshavardhan C SavitrinarayanaDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Sisila ValappilDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Tanushree AgarwalDepartment of Chemistry, Centre for Misfolding Disease, University of Cambridge, Cambridge, UK.
Rob M ScruttonDepartment of Chemistry, Centre for Misfolding Disease, University of Cambridge, Cambridge, UK.
Laiba MaryamDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Asma GulzarDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Jinying WangDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, NJ 08854, USA.
Dominic J TiganiDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.
Liege A PascoalinoDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Akshay V JadhavDepartment of Civil and Environmental Engineering, Syracuse University, Syracuse, NY 13244, USA.
Albert L AdhyaDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.
Alaji BahDepartment of Biochemistry and Molecular Biology, SUNY Upstate Medical University, Syracuse, NY 13210, USA.
Zhao QinDepartment of Civil and Environmental Engineering, Syracuse University, Syracuse, NY 13244, USA.
Zheng ShiDepartment of Chemistry and Chemical Biology, Rutgers, The State University of New Jersey, NJ 08854, USA.
Michael R BlatchleyDepartment of Biomedical and Chemical Engineering, Syracuse University, Syracuse, NY 13244, USA.
Jianhan ChenDepartment of Chemistry, University of Massachusetts, Amherst, MA 01003, USA.
Tuomas P J KnowlesDepartment of Chemistry, Centre for Misfolding Disease, University of Cambridge, Cambridge, UK.
Davoud MozhdehiDepartment of Chemistry, Syracuse University, Syracuse, NY 13244, USA.

Funding

University of Colorado Cancer Center Support Grant - Lung Cancer Patient-Derived Xenografts with Autologous Human Immune SystemsP30CA046934 · NCI · UNIVERSITY OF COLORADO DENVER · PI James V Degregori · 1988 to 2026
$117.0M
University of Colorado Anschutz Medical Campus DRCP30DK116073 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI LORI SUSSEL · 2020 to 2026
$10.8M
Role of DNA Methylation in Liquid-liquid Phase Separation-mediated Heterochromatin FormationR35GM138097 · NIGMS · UPSTATE MEDICAL UNIVERSITY · PI BAH, ALAJI · 2020 to 2024
$2.2M
Disordered Proteins and Dynamic Interactions in Biology and Diseases.R35GM144045 · NIGMS · UNIVERSITY OF MASSACHUSETTS AMHERST · PI Jianhan Chen · 2022 to 2026
$2.0M
Genetically Encoded Lipidation to Manipulate Structure, Assembly, and Phase Behavior of ProteinsR35GM142899 · NIGMS · SYRACUSE UNIVERSITY · PI MOZHDEHI , DAVOUD · 2021 to 2025
$1.8M
Understanding the viscoelasticity, surface tension, and membrane interactions of biomolecular condensates in live cellsR35GM147027 · NIGMS · RUTGERS, THE STATE UNIV OF N.J. · PI Zheng Shi · 2022 to 2026
$1.6M
4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and formR00DK135907 · NIDDK · SYRACUSE UNIVERSITY · PI Michael Blatchley · 2024 to 2026
$747k
4D controllable extracellular matrix properties to guide iPSC-derived intestinal organoid fate and formK99DK135907 · NIDDK · UNIVERSITY OF COLORADO · PI BLATCHLEY, MICHAEL · 2023 to 2023
$90k
NCI NIH HHS P30 CA046934NIDDK NIH HHS K99 DK135907NIDDK NIH HHS P30 DK116073NIDDK NIH HHS R00 DK135907NIGMS NIH HHS R35 GM138097NIGMS NIH HHS R35 GM142899NIGMS NIH HHS R35 GM144045NIGMS NIH HHS R35 GM147027
6 · The paper itself

Abstract

Cells use post-translational modifications (PTMs) to reconfigure biomolecular condensates across length scales, space, and time.

Identifiers

PMID41993480
PMCPMC13081844

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.