Evidence map›Paper›PMID 41993471›Full record

ArticlebioRxiv : the preprint server for biology2026

Aging restricts maturation of CXCL13

Nathan A Bracey, Casey Beppler, Tatjana Bilich, Adrienne H Long, Elsa Sola, Aviv Barak, Timothy J Few-Cooper, Azam Mohsin, Vishnu Shankar, Vamsee Mallajosyula and 4 more

Abstract readPreprint
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors.

Nathan A BraceyDepartment of Medicine; Department of Microbiology, Immunology and Infectious Diseases, University of Calgary, Calgary, AB, Canada.ORCID 0000-0001-7938-1691
Casey BepplerInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0001-9241-2413
Tatjana BilichInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-8107-0419
Adrienne H LongInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-1523-9095
Elsa SolaInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Aviv BarakDepartment of Immunology, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0009-0005-8081-9642
Timothy J Few-CooperDepartment of Immunology, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0009-0009-3775-4547
Azam MohsinInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-0021-3244
Vishnu ShankarInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Vamsee MallajosyulaInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0002-0658-3652
Lilit KamalyanInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.
Robson CapassoDivision of Sleep Surgery, Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA, USA.ORCID 0000-0003-2645-1793
Shai S Shen-OrrDepartment of Immunology, Faculty of Medicine, Technion - Israel Institute of Technology, Haifa, Israel.ORCID 0000-0002-6991-7736
Mark M DavisInstitute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA, USA.

Funding

Using a tonsil organoid system to probe conditions for the induction of protective antibody and T cell responses to influenza.U19AI057229 · NIAID · STANFORD UNIVERSITY · PI Mark Morris Davis · 2003 to 2026
$88.5M
The effects of immune-age on immune-response and the molecular mechanisms which drive itP01AI153559 · NIAID · STANFORD UNIVERSITY · PI DAVIS, MARK MORRIS · 2021 to 2025
$17.8M
CXCL13 as an aging-associated defect in memory T cell homeostasisF32AI186256 · NIAID · STANFORD UNIVERSITY · PI Casey Beppler · 2024 to 2026
$193k
NIAID NIH HHS F32 AI186256NIAID NIH HHS P01 AI153559NIAID NIH HHS U19 AI057229
6 · The paper itself

Abstract

A decline in specific antibody responses is a hallmark of human aging, yet the differential contributions of B and T lymphocytes and their interactions remain unclear. CXCL13 is a critical chemokine that shapes germinal center organization, but the regulation of human-specific CXCL13

Indexed as

agingCXCL13gene regulationhuman immunologymaturationTfh cells

Identifiers

PMID41993471
PMCPMC13082170

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.