Evidence map›Paper›PMID 41993460›Full record

ArticlebioRxiv : the preprint server for biology2026

Sulfide:quinone oxidoreductase drives mitochondrial supersulfide metabolism to regulate bioenergetics and longevity in eukaryotes.

Jia Yao, Tetsuro Matsunaga, Akira Nishimura, Meg Shieh, Tomoaki Ida, Minkyung Jung, Seiryo Ogata, Tsuyoshi Takata, Uladzimir Barayeu, Hozumi Motohashi and 2 more

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Jia YaoDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Tetsuro MatsunagaDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Akira NishimuraDivision of Agriculture, Graduate School of Arts and Sciences, Iwate University, Iwate 020-8550, Japan.
Meg ShiehDepartment of Chemistry, Brown University, Providence, Rhode Island 02912, USA.
Tomoaki IdaDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Minkyung JungDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Seiryo OgataDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Tsuyoshi TakataDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Uladzimir BarayeuDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Hozumi MotohashiDepartment of Medical Biochemistry, Graduate School of Medicine Tohoku University, Sendai 980-8575, Japan.
Masanobu MoritaDepartment of Environmental Medicine and Molecular Toxicology, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.
Takaaki AkaikeDepartment of Redox Molecular Medicine, Tohoku University Graduate School of Medicine, Sendai 980-8575, Japan.

Funding

Probing the cardioprotective effects of sulfane sulfurs with next generation fluorescent sensorsF31HL170516 · NHLBI · BROWN UNIVERSITY · PI SHIEH, MEG · 2023 to 2025
$146k
NHLBI NIH HHS F31 HL170516
6 · The paper itself

Abstract

Sulfide:quinone oxidoreductase (SQR) is a critical enzyme that maintains sulfur metabolism by oxidizing sulfide to supersulfides, currently defined as sulfur metabolites with six valence electrons and no charge that are covalently catenated with other sulfur atoms and excludes disulfides. While SQR is known to contribute to mitochondrial electron transport, its physiological impact on systemic energy metabolism and longevity remains largely undefined. In this study, we investigated the role of SQR in mitochondrial bioenergetics and aging using SQR-deficient

Indexed as

BiochemistryBiological Sciencesmitochondrial energy metabolismmouse embryonic fibroblastsulfide:quinone oxidoreductasesupersulfidesyeast lifespan

Identifiers

PMID41993460
PMCPMC13082054

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.