Evidence map›Paper›PMID 41993459›Full record

ArticlebioRxiv : the preprint server for biology2026

Ancient IL-6-STAT5 signaling orchestrates inflammation in jawless vertebrates.

Francisco Fontenla-Iglesias, Jean-Louis Boulay, Jonathan P Rast, Masayuki Hirano, Byron B Au-Yeung, Jesús Lamas, Weiming Li, Thomas Boehm, Max D Cooper, Sabyasachi Das

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Francisco Fontenla-IglesiasDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-5760-5102
Jean-Louis BoulayDepartment of BioMedicine, University Hospital Basel and University of Basel, Hebelstrasse 20,4031 Basel, Switzerland.ORCID 0000-0002-1401-7159
Jonathan P RastDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0001-6494-0403
Masayuki HiranoDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-2455-9189
Byron B Au-YeungEmory University School of Medicine, Department of Medicine, Division of Immunology, Lowance Center for Human Immunology, Atlanta, GA, USA.ORCID 0000-0002-6446-9102
Jesús LamasDepartment of Functional Biology, Cell Biology Unit, CIBUS Building, Aquatic Research Institute for Global Health (iARCUS), University of Santiago de Compostela, Santiago de Compostela, Spain.ORCID 0000-0002-9702-7140
Weiming LiDepartment of Fisheries and Wildlife, Michigan State University, East Lansing, MI, USA.ORCID 0000-0001-5437-1518
Thomas BoehmDepartment of Developmental Immunology, Max-Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany.ORCID 0000-0001-5172-7478
Max D CooperDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0003-0887-8785
Sabyasachi DasDepartment of Pathology and Laboratory Medicine, Emory University, Atlanta, GA, USA.ORCID 0000-0002-9116-9623

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Characterization of the Lamprey Adaptive Immune SystemR01AI072435 · NIAID · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI Max Dale Cooper · 2007 to 2026
$8.1M
T Cell Differentiation and Diversification in Jawless Vertebrates: Administrative Supplement for purchase of Laser Capture MicroscopeR35GM122591 · NIGMS · EMORY UNIVERSITY · PI Max Dale Cooper · 2017 to 2026
$4.7M
Characterization of an Alternative Adaptive Immune System in HagfishR01GM108838 · NIGMS · EMORY UNIVERSITY · PI COOPER, MAX DALE · 2014 to 2016
$889k
NIAID NIH HHS R01 AI072435NIGMS NIH HHS R01 GM108838NIGMS NIH HHS R35 GM122591NIH HHS P51 OD011132
6 · The paper itself

Abstract

Interleukin-6 (IL-6) is a central regulator of vertebrate immunity, yet its existence in jawless vertebrates has remained obscure because of extreme sequence divergence. The extant jawless vertebrates (lampreys and hagfish), which deploy variable lymphocyte receptors (VLRs) instead of immunoglobulins and T cell receptors, provide a unique window into the earliest interface between cytokines and adaptive immunity. Here, we identify

Indexed as

CyclostomesCytokine evolutionIL-6STAT signalingVLR-based immunity

Identifiers

PMID41993459
PMCPMC13081863

What OpenQuestion holds

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LicenceCC BY-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.