ArticlebioRxiv : the preprint server for biology2026
DnaE uses strand displacement synthesis during Okazaki fragment repair.
Article in bioRxiv : the preprint server for biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
RNA serves the essential role of priming DNA replication for all organisms. In bacteria, it is estimated that more than 20,000 ribonucleotides accumulate on the lagging strand per round of replication. Despite the importance of RNA primers in initiating DNA synthesis, unresolved primers result in strand breaks and induction of the DNA damage response, leading to genome instability. In bacteria, the prevailing model suggests that DNA polymerase I (Pol I) replaces RNA primers with DNA during lagging strand replication. However, in
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